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Biosensor-based assay of exosome biomarker for early diagnosis of cancer
《医学前沿(英文)》 2022年 第16卷 第2期 页码 157-175 doi: 10.1007/s11684-021-0884-z
Glyco-functionalised quantum dots and their progress in cancer diagnosis and treatment
Jayshree Ashree, Qi Wang, Yimin Chao
《化学科学与工程前沿(英文)》 2020年 第14卷 第3期 页码 365-377 doi: 10.1007/s11705-019-1863-7
关键词: carbohydrate leptin glyco-functionalised QD bioimaging cancer diagnosis and treatment
Exploring the diagnosis markers for gallbladder cancer based on clinical data
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《医学前沿(英文)》 2015年 第9卷 第3期 页码 350-355 doi: 10.1007/s11684-015-0402-2
Presently, no effective markers are available to facilitate gallbladder cancer (GBC) diagnosis. This study aims to explore available markers for GBC diagnosis. Clinical data of 144 GBC and 116 cholelithiasis patients were retrospectively reviewed. Logistic regression analysis was performed to evaluate GBC risk factors. A receiver operating characteristic (ROC) curve was used to assess the diagnosis value of the risk factors. By comparing the characteristic of GBC and cholelithiasis patients, the following factors exhibited statistical difference: age, gender, gallstones, total bilirubin (TB), alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), platelet count (PLT), CA125 (carcinoembryonic antigen 125), and CA199 (carbohydrate antigen 199). Logistic regression analysis indicated that age [odds ratio (OR), 1.032; 95% confidence interval (95% CI), 1.004 to 1.061; P = 0.024], gender (OR, 0.346; 95% CI, 0.167 to 0.716; P = 0.004), gallstones (OR, 0.027; 95% CI, 0.007 to 0.095; P<0.001), ALP (OR, 1.003; 95% CI, 1.000 to 1.006; P = 0.032), TB (OR, 1.004; 95% CI, 1.000 to 1.009; P = 0.042), and CA125 (OR, 1.007; 95% CI, 1.002 to 1.013; P = 0.011) were independent risk factors for GBC. According to the ROC curve, CA125 [area under curve (AUC), 0.720], ALP (AUC, 0.713), TB (AUC, 0.636), and age (AUC, 0.573) were valuable diagnosis markers. Additionally, based on the independent risk factors, the GBC diagnosis model was established. Age, TB, ALP, and CA125 can be used as auxiliary diagnosis factors of GBC. The diagnosis model provides a quantitative tool for GBC diagnosis when comprehensively considering various risk factors.
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《医学前沿(英文)》 2013年 第7卷 第2期 页码 157-171 doi: 10.1007/s11684-013-0272-4
Non-small-cell lung cancer (NSCLC) is the most common cause of premature death among the malignant diseases worldwide. The current staging criteria do not fully capture the complexity of this disease. Molecular biology techniques, particularly gene expression microarrays, proteomics, and next-generation sequencing, have recently been developed to facilitate effectively its molecular classification. The underlying etiology, pathogenesis, therapeutics, and prognosis of NSCLC based on an improved molecular classification scheme may promote individualized treatment and improve clinical outcomes. This review focuses on the molecular classification of NSCLC based on gene expression microarray technology reported during the past decade, as well as their applications for improving the diagnosis, staging and treatment of NSCLC, including the discovery of prognostic markers or potential therapeutic targets. We highlight some of the recent studies that may refine the identification of NSCLC subtypes using novel techniques such as epigenetics, proteomics, or deep sequencing.
关键词: non-small-cell lung cancer molecular typing individualized medicine molecular-targeted therapy gene expression profiling
Design and evaluation of a novel biopsy needle with hemostatic function
《机械工程前沿(英文)》 2023年 第18卷 第2期 doi: 10.1007/s11465-022-0738-7
关键词: cancer diagnosis biopsy needle hemostatic function predictive model coupled Eulerian−Lagrangian
纳米技术和纳米医学——肺癌诊断和治疗的希望之路 Review
尹伟, 潘峰, 朱俊杰, 徐军武, Diego Gonzalez-Rivas, Meinoshin Okumura, 唐志勇, 杨洋
《工程(英文)》 2021年 第7卷 第11期 页码 1577-1585 doi: 10.1016/j.eng.2020.04.017
肺癌是全球最常见的癌症,五年总生存率非常低。肺癌的常规诊断和治疗策略具有内在局限性,这就推动了纳米技术和纳米医学方法的发展,以提高早期诊断率并开发更有效、更安全的肺癌治疗方案。癌症纳米医学旨在根据每个患者独特的生理和病理特征(在基因组和蛋白质组水平上)来制定药物递送、诊断和治疗方案,在该领域引起广泛关注。尽管纳米医学技术在肺癌的科学研究中获得成功应用,但由于对纳米技术与生物学之间的相互作用知之甚少,以及毒理学、药理学、免疫学和纳米颗粒的大规模制造等方面的挑战,使得纳米医学方法的临床转化仍然具有挑战性。在本文中,我们强调了用于肺癌治疗的纳米医学的发展和机遇,并展望了该领域的前景,以及讨论了其在临床转化中面临的挑战。
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《医学前沿(英文)》 2015年 第9卷 第3期 页码 261-274 doi: 10.1007/s11684-015-0406-y
Environmental pollution is one of the main causes of human cancer. Exposures to environmental carcinogens result in genetic and epigenetic alterations which induce cell transformation. Epigenetic changes caused by environmental pollution play important roles in the development and progression of environmental pollution-related cancers. Studies on DNA methylation are among the earliest and most conducted epigenetic research linked to cancer. In this review, the roles of DNA methylation in carcinogenesis and their significance in clinical medicine were summarized, and the effects of environmental pollutants, particularly air pollutants, on DNA methylation were introduced. Furthermore, prospective applications of DNA methylation to environmental pollution detection and cancer prevention were discussed.
关键词: environmental pollution DNA methylation cancer biomarker diagnosis therapy prevention
《医学前沿(英文)》 2021年 第15卷 第6期 页码 942-942 doi: 10.1007/s11684-021-0876-z
Laboratory diagnosis for malaria in the elimination phase in China: efforts and challenges
《医学前沿(英文)》 2022年 第16卷 第1期 页码 10-16 doi: 10.1007/s11684-021-0889-7
关键词: malaria laboratory diagnosis quality control malaria elimination China
Tomographic diagnosis of defects in hydraulic concrete structure
ZHAO Mingjie, XU Xibin
《结构与土木工程前沿(英文)》 2008年 第2卷 第3期 页码 226-232 doi: 10.1007/s11709-008-0027-5
关键词: satisfactory processing orientation tomographic diagnosis orientation perpendicular
《机械工程前沿(英文)》 2021年 第16卷 第4期 页码 814-828 doi: 10.1007/s11465-021-0650-6
关键词: bearing cross-severity fault diagnosis hierarchical fault diagnosis convolutional neural network decision tree
《机械工程前沿(英文)》 2022年 第17卷 第3期 doi: 10.1007/s11465-022-0689-z
关键词: surrogate model gas face seal fault diagnosis nonlinear dynamics tribology
Machine learning for fault diagnosis of high-speed train traction systems: A review
《工程管理前沿(英文)》 doi: 10.1007/s42524-023-0256-2
关键词: high-speed train traction systems machine learning fault diagnosis
Progress and challenges in RET-targeted cancer therapy
《医学前沿(英文)》 2023年 第17卷 第2期 页码 207-219 doi: 10.1007/s11684-023-0985-y
关键词: pralsetinib selpercatinib RET-alteration lung cancer thyroid cancer tumor-agnostic therapy drug resistance
Epithelial-to-mesenchymal transition in cancer: complexity and opportunities
Yun Zhang, Robert A. Weinberg
《医学前沿(英文)》 2018年 第12卷 第4期 页码 361-373 doi: 10.1007/s11684-018-0656-6
The cell-biological program termed the epithelial-to-mesenchymal transition (EMT) plays an important role in both development and cancer progression. Depending on the contextual signals and intracellular gene circuits of a particular cell, this program can drive fully epithelial cells to enter into a series of phenotypic states arrayed along the epithelial-mesenchymal phenotypic axis. These cell states display distinctive cellular characteristics, including stemness, invasiveness, drug-resistance and the ability to form metastases at distant organs, and thereby contribute to cancer metastasis and relapse. Currently we still lack a coherent overview of the molecular and biochemical mechanisms inducing cells to enter various states along the epithelial-mesenchymal phenotypic spectrum. An improved understanding of the dynamic and plastic nature of the EMT program has the potential to yield novel therapies targeting this cellular program that may aid in the management of high-grade malignancies.
关键词: epithelial-to-mesenchymal transition cancer metastasis cancer stem cell
标题 作者 时间 类型 操作
Glyco-functionalised quantum dots and their progress in cancer diagnosis and treatment
Jayshree Ashree, Qi Wang, Yimin Chao
期刊论文
Molecular classification of non-small-cell lung cancer: diagnosis, individualized treatment, and prognosis
null
期刊论文
Environmental pollution and DNA methylation: carcinogenesis, clinical significance, and practical applications
null
期刊论文
Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer
期刊论文
convolutional tree-inspired network: a decision-tree-structured neural network for hierarchical fault diagnosis
期刊论文
Method for solving the nonlinear inverse problem in gas face seal diagnosis based on surrogate models
期刊论文